Personally, I pour in about half a bottle, and let is sit in there at least overnight and put about 50 miles or so on the car. You're not going to clog your oil passages with the sludge it breaks off, it dissolves the sludge into the oil, so the filter can catch it... which is why it's so important to change your filter after you do it.
Some people will disagree about driving a lot with it in there, but I disagree since I have the experience of doing it to pretty much every single car I've ever owned with mileage ranging from almost 200k miles to as low as 50k, with both dino and synthetic oils. So it's really a matter of what you feel comfortable doing. However, think about it this way: do you really think something like Seafoam is going to be able to dissolve years of sludge and dirt from you engine in twenty minutes? I doubt it. Give it time to do it's thing.
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